Day 1 | Wednesday May 3

Day 1 | Wednesday May 3
"Wowterworld" (A. Di Martino/Colapesce in "The bad guy") 12:00 - 16:40
SEMINAR Chairs: Francesco Patti (Catania) & Giuseppe Salemi (Palermo) 12:00-12:30 | Il-6 in the spotlight: Progress in Neuroimmunology Angus Byars (Principal Global Medical Director, Roche) 12:30-13:00 | Treat to target: new therapeutic approaches in Multiple Sclerosis Renato Turrini (Medical Head Neurosciences, Novartis Italia)
Lunch Break 13:00 - 14:00
SEMINARS Chair: Sebastiano Bucello (Siracusa) & Luigi Maria E. Grimaldi (Cefalù) 14:00-14:30 | From biological challenges to biotechnological advance: the value of CD19 depletion Silvia Rossi, MD, PhD (Director Medical Affairs Lead Italy, Horizon Therapeutics) 14:30-15:00 | argenx commitment in rare autoimmune diseases Fien Verhamme (Clinical Scientist, argenx) 15:00-15:30 | Future perspectives in Multiple Sclerosis & Neurology Pascal Rufi (Global Neurology and Immunology Medical Affairs, Sanofi) 15:30-16:00 | L’inibizione del sistema complemento: quali evidenze, quali prospettive e future aree di ricerca Fabio Buelli MD, PhD (Therapeutic Area Lead Neurology, Alexion) 16:00-16:40 | Applying advances in CNS to accelerate drug discovery and development Paola Marcon (Director Clinical Country & Site Management, Biogen)
Coffee Break 16:40 - 17:15
"Nuovo Cinema Paradiso" (E. Morricone, original sound track) 17:15 - 18:00
WELCOME REMARKS Chairs: Roberto Furlan (Milan), Giovanna Borsellino (Rome), Gabriela Constantin (Verona) & Paolo Ragonese (Palermo) 17:15-17:30 | Welcome Remarks Local Organizing Committee
PLENARY LECTURE Chairs: Davide Maimone (Catania) & Paolo Ragonese (Palermo) 17:30-18:00 | Regulatory neutrophils in neuroinflammation Roberto Furlan (San Raffaele Scientific Institute - Milan, Italy)
SOCIAL EVENT 18:15...
Orto Botanico | Università degli Studi di Palermo Offical Welcome by the Dean of the University fo Palermo Prof. Massimo Midiri & Prof. Francesco Dieli Welcome Cocktail

Day 2 | Thursday May 4

Day 2 | Thursday May 4
"E ti vengo a cercare" (by F. Battiato in "I figli degli uomini") 09:00 - 11:00
AUTOIMMUNE NEUROLOGY Chairs: Diana Ferraro (Modena) & Matteo Gastaldi (Pavia) 09:00-09:30 | Neuropathology of Antibody-Mediated Encephalitis and Demyelinating Diseases Romana Höfteberger (Medical University of Vienna - Vienna, Austria) 09:30-10:00 | Neuromyelitis Optica Spectrum Disorders: from Pathophysioloty to Therapeutic Strategies Carla Tortorella (Ospedale San Camillo Forlanini - Rome, Italy) Oral Presentations 10:00-10:15 | #32 A retrospective comparative study of autoimmune comorbidities in Autoimmune Encephalitis and Multiple Sclerosis Giorgia Teresa Maniscalco (“A. Cardarelli” Hospital - Naples, Italy) 10:15-10:30 | #36 Anti-LGI1 encephalitis: A family affair Pierludovico Moro (Sapienza University – Rome, Italy) 10:30-10:45 | TBD TBD (TBD) 10:45-11:00 | #34 Optimization of a screening assay for antibody-mediated complement activation (ACA) in autoimmune neurological disorders Pietro Businaro (University of Pavia/IRCCS Mondino Foundation – Pavia, Italy)
Coffee Break 11:00 - 11:30
"U sfrusciò d'u mari" (by O. Sellerio in Il Commisario Montalbano, "La rete di protezione") 11:30 - 13:30
VISUALISING NEURODEGENERATION Chairs: Bruno Bonetti (Verona) & Claudio Gasperini (Rome) 11:30-12:00 | MRI Single Cell Transcriptomics of Chronic Active Inflammation in Multiple Sclerosis Martina Absinta (Ospedale San Raffaele - Milan, Italy) 12:00-12:30 | Compartmentalized Inflammation in Multiple Sclerosis Driver of Disease Progression? Roberta Magliozzi (Università di Verona - Verona, Italy) Oral Presentations 12:30-12:45 | #5 Increased signal transduction mediated by extracellular vesicles Giulia Marostica (IRCCS Ospedale San Raffaele – Milan, Italy) 12:45-13:00 | #9 Resolution of inflammation is impaired in Parkinson’s disease and is rescued by specialized pro-resolving lipid mediator RvD1 through targeting microglia and brain-infiltrating macrophages Marta Tiberi (IRCCS Santa Lucia Foundation – Rome, Italy) 13:00-13:15 | #15 Accelerated cellular senescence in progressive Multiple Sclerosis Elena Barusolo (University of Verona – Verona, Italy) 13:15-13:30 | #41 Reconstruction and analysis of interaction networks between amyloid-beta deposits and myeloid immune cells in Alzheimer’s disease Aferdita Suli (University of Verona – Verona, Italy)
Lunch Break & Poster Session 13:30 - 15:30
POSTER SESSION Chairs: Rosella Mechelli (Rome) & Claudio Procaccini (Naples) #4 Endocannabinoid system and neuroinflammation: testing novel monoacylglycerol lipase-protein degrader in Experimental Autoimmune Encephalomyelitis Roberta Amoriello (University of Florence – Florence, Italy) #6 Influence of FCGR3A-V158F polymorphisms on the therapeutic response to Ocrelizumab in patients with Multiple Sclerosis Giuseppina Miele (University of Campania Luigi Vanvitelli - Naples, Italy) #7 An in-depth appraisal of cytokine-induced killer (CIK) cells in glioblastoma Giacomo Sferruzza (Università Vita-Salute San Raffaele – Milan, Italy) #8 IL-9 inhibits NF-kB pathway in human reactive astrocytes Miriam Cinotti (Santa Lucia Foundation – Rome, Italy) #11 IL-9/IL-9 receptor signaling is active in murine neurons from spinal cord Costanza Stacchiotti (Santa Lucia Foundation – Rome, Italy) #13 Anti-CV2/CRMP5 Extrapiramidal Immune-Mediated Encephalitis Induced by Immune Checkpoint Blockade in a Patient with Extensive Small Cell Lung Cancer Maria Teresa Ferrò (ASST Crema – Lodi, Italy) #16 BACE1 influence clinical manifestations and central inflammation in relapsing remitting multiple sclerosis Antonio Bruno (Università degli studi di Roma Tor Vergata – Rome, Italy) #17 Brain white matter lesions’ microstructure as potential predictor of CRS and ICANS development following CAR-T treatment Maria Matilde Inglese (University of Genova – Genoa, Italy) #18 A single nucleotide variant of IL-5 gene influences neuroinflammation and clinical outcome measurements in multiple sclerosis Ettore Dolcetti (IRCCS Neuromed - Pozzilli, Italy) #19 Serine 11 phosphorylation regulates dCK intracellular localization in T cells predicting their response to cladribine treatment Federico Carlini (IRCCS Ospedale Policlinico San Martino - Genova, Italy) #21 Beta-3 adrenergic receptors in mesenchymal stem cells control the expression of factors involved in the modulation of hematopoiesis by activating mTOR signalling Maria Cristina Mariani (DINOGMI, University of Genoa – Genoa, Italy) #23 Circulating AgRP neuropeptide: a new mediator of neuro-immune crosstalk in neurodegenerative diseases? Eleonora Cornacchia (IRCCS Ospedale Policlinico San Martino – Genoa, Italy) #24 Specific T-cell responses to Varicella Zoster Virus glycoprotein E after vaccination with a recombinant adjuvanted subunit vaccine in patients with multiple sclerosis on immune modulating treatments Francesca Napoli (Università degli studi di Roma Tor Vergata – Rome, Italy) #26 Astrocyte TrkB supports injury in ischemic stroke Emanuela Colombo (San Raffaele Scientific Institute – Milan, Italy) #28 Application of GreatNector as a data-driven workflow in Multiple Sclerosis Alessandro Maglione (Department of Clinical and Biological Sciences, University of Turin – Turin, Italy) #29 Nutrient-specific control of immunological self-tolerance in Experimental Autoimmune Encephalomyelitis Claudia Russo (Fondazione Santa Lucia IRCCS – Rome, Italy) #30 Identification of immuno-miRs as biomarkers associated with response to immunosuppressive treatment in myasthenia gravis Nicola Iacomino (Fondazione IRCCS Istituto Neurologico Carlo Besta - Milan, Italy) #31 Whole miRNome sequencing in myasthenia gravis thymus reveals dysregulated miRNA/target gene networks implicated in autoimmunity Maria Cristina Tarasco (Fondazione IRCCS Istituto Neurologico Carlo Besta - Milan, Italy) #38 Prognostic relevance of quantitative and longitudinal CASPR2 and LGI1 antibody testing in patients with autoimmune encephalitis. Ruggero Barnabei (Fondazione Mondino – Pavia, Italy) #39 Proinflammatory MAIT cells react to gut flora yeasts and infiltrate brain in multiple sclerosis patients Gisella Guerrera (Santa Lucia Foundation IRCCS – Rome, Italy) #43 Characterization of new bioactive molecules for the treatment of neuroinflammatory and neurodegenerative diseases Pallab Majumder (University of Verona – Verona, Italy) #45 Isolated Retrograde Amnesia in anti-CASPR2 Encephalitis: A Case Series and Systematic Literature Review Antonio Malvaso (IRCCS "C. Mondino" Foundation - National Neurological Institute – Pavia, Italy) #46 Subgroup outcomes from RAISE: A randomised, Phase 3 trial of zilucoplan in generalised myasthenia gravis Matteo Gastaldi (IRCCS Mondino Foundation - Pavia, Italy) #47 Long-term efficacy and safety of symptom-driven cyclic rozanolixizumab treatment in patients with generalised myasthenia gravis: A pooled analysis of a Phase 3 study and two open-label extension studies Matteo Gastaldi (IRCCS Mondino Foundation - Pavia, Italy) #48 Re-emergence of T lymphocytes-mediated synaptopathy in progressive multiple sclerosis Sara Balletta (IRCCS Ist. Neurologico Neuromed – Rome, Italy) #49 MiRNA-106a in cell- free cerebrospinal fluid as signature of early Relapsing Multiple Sclerosis Virginia Manuti (Università degli studi di Foggia – Foggia, Italy) #51 Head-to-head comparison of fixed versus live cell-based assays for AQP4-IgG detection in real-life diagnostic setting Mario Risi (University of Campania "Luigi Vanvitelli" – Naples, Italy) #52 An atypical case of progressive disease in MOGAD Massimiliano Ugo Verza (University of Florence – Florence, Italy) #55 Synaptic sexual dimorphism in multiple sclerosis and experimental autoimmune encephalomyelitis mouse model Alice Tartacca (Tor Vergata University, Rome, Italy – Rome, Italy) #58 Immunological patterns characterizing anti-CD20 therapy in Multiple Sclerosis: a longitudinal study Manolo Sambucci (IRCCS Fondazione Santa Lucia – Rome, Italy)
“Cu ti lu dissi” by R. Balistreri (in Palermo shooting) 15:30 - 17:30
CNS BORDERS Chairs: Gabriela Constantin (Verona) & Cinthia Farina (Milan) 15:30-16:00 | The other brain barrier Jonathan Kipnis (Washington University in St. Louis, School of Medicine - St. Louis, USA) Oral Presentations 16:00-16:15 | #22 AgRP neurons regulate hematopoiesis and Treg generation through beta 3 adrenergic receptor-expressing stromal cells Tiziana Vigo (IRCCS Ospedale Policlinico San Martino – Genoa, Italy) 16:15-16:30 | #42 A role for immune cell crosstalks in central nervous system autoimmune diseases Alessandro Bani (University of Verona – Verona, Italy) 16:30-16:45 | #35 Functional and phenotypic flow cytometry analysis of immune cells in CSF and whole blood of patients with multiple sclerosis Alice Verdiani (Fondazione Santa Lucia – Rome, Italy) 16:45-17:00 | #3 PD-L2 identifies a novel subpopulation of neutrophils displaying immunoregulatory features in Multiple Sclerosis Susanna Manenti (San Raffaele Scientific Institute – Milan, Italy) 17:00-17:15 | #50 IL-9 regulates microglia-driven synaptotoxicity and neurodegeneration in experimental multiple sclerosis Alessandra Musella (Università Telematica San Raffaele – Rome, Italy) 17:15-17:30 | #14 Hypogammaglobulinemia and severe infections in Multiple Sclerosis patients on anti-CD20 agents: a multicentre study Krzysztof Smolik (Università degli studi di Modena e Reggio Emilia – Modena, Italy)
Coffee Break 17:30 - 18:00
SPECIAL TALK I Chairs: Tiziana Vigo (Genoa) & Luca Battistini (Rome) 18:00-18:30 | AI in healthcare: from cloud to bedside Carlo Tacchetti (IRCCS Ospedale San Raffaele Scientific Institute - Milan, Italy)
SOCIAL EVENT 19:15 - 20:15
AINI ANNUAL FOOTBALL MATCH South vs North

Day 3 | Friday May 5

Day 3 | Friday May 5
"L'ultimo bacio" (by C. Consoli) 09:15 - 12:15
VIRUSES & INFECTION Chairs: Giovanna Borsellino (Rome) & Marco Salvetti (Rome) 09:15-10:00 | Infectious triggers of multiple sclerosis - EBV and other candidates and how they may induce and perpetuate disease Roland Martin (University Hospital Zurich - Zurich, Switzerland) Oral Presentation 10:00-10:15 | #12 Ocrelizumab modulates phenotype and effector function of CD8+ T cells in Relapsing Multiple Sclerosis Gianmarco Abbadessa (University of Campania Luigi Vanvitelli – Naples, Italy) 10:15-10:30 | #25 Gut, skin and oral microbiome in Multiple Sclerosis: a Mendelian Randomization analysis Gianmarco Bellucci (Sapienza, University of Rome - Rome, Italy) 10:30-10:45 | #27 Epstein-Barr Virus activates regulatory T-cells in multiple sclerosis to produce pro- and anti-inflammatory cytokines Jens Albrecht Ernst Geginat (DISCCO, Università degli studi di Milano e INGM – Milan, Italy) 10:45-11:00 | #56 Do viral genetic variants contribute to the EBV role in multiple sclerosis? Rosella Mechelli (Università San Raffale Roma – Rome, Italy) 11:00-11:15 | #37 The immune landscape of antiviral responses in multiple sclerosis Silvia D'Orso (Santa Lucia Foundation – Rome, Italy)
Coffee Break 11:15-11:45
SPECIAL TALK II Chairs: Diego Centonze (Rome) & Antonio Uccelli (Genoa) 11:45-12:15 | Neural stem cells from biology to therapy Gianvito Martino (San Raffaele Scientific Institute - Milan, Italy)
Lunch Break 12:15-14:15
POSTER SESSION Chairs: Serena Meraviglia (Palermo) & Martina Severa (Rome) #4 Endocannabinoid system and neuroinflammation: testing novel monoacylglycerol lipase-protein degrader in Experimental Autoimmune Encephalomyelitis Roberta Amoriello (University of Florence – Florence, Italy) #6 Influence of FCGR3A-V158F polymorphisms on the therapeutic response to Ocrelizumab in patients with Multiple Sclerosis Giuseppina Miele (University of Campania Luigi Vanvitelli - Naples, Italy) #7 An in-depth appraisal of cytokine-induced killer (CIK) cells in glioblastoma Giacomo Sferruzza (Università Vita-Salute San Raffaele – Milan, Italy) #8 IL-9 inhibits NF-kB pathway in human reactive astrocytes Miriam Cinotti (Santa Lucia Foundation – Rome, Italy) #11 IL-9/IL-9 receptor signaling is active in murine neurons from spinal cord Costanza Stacchiotti (Santa Lucia Foundation – Rome, Italy) #13 Anti-CV2/CRMP5 Extrapiramidal Immune-Mediated Encephalitis Induced by Immune Checkpoint Blockade in a Patient with Extensive Small Cell Lung Cancer Maria Teresa Ferrò (ASST Crema – Lodi, Italy) #16 BACE1 influence clinical manifestations and central inflammation in relapsing remitting multiple sclerosis Antonio Bruno (Università degli studi di Roma Tor Vergata – Rome, Italy) #17 Brain white matter lesions’ microstructure as potential predictor of CRS and ICANS development following CAR-T treatment Maria Matilde Inglese (University of Genova – Genoa, Italy) #18 A single nucleotide variant of IL-5 gene influences neuroinflammation and clinical outcome measurements in multiple sclerosis Ettore Dolcetti (IRCCS Neuromed - Pozzilli, Italy) #19 Serine 11 phosphorylation regulates dCK intracellular localization in T cells predicting their response to cladribine treatment Federico Carlini (IRCCS Ospedale Policlinico San Martino - Genova, Italy) #21 Beta-3 adrenergic receptors in mesenchymal stem cells control the expression of factors involved in the modulation of hematopoiesis by activating mTOR signalling Maria Cristina Mariani (DINOGMI, University of Genoa – Genoa, Italy) #23 Circulating AgRP neuropeptide: a new mediator of neuro-immune crosstalk in neurodegenerative diseases? Eleonora Cornacchia (IRCCS Ospedale Policlinico San Martino – Genoa, Italy) #24 Specific T-cell responses to Varicella Zoster Virus glycoprotein E after vaccination with a recombinant adjuvanted subunit vaccine in patients with multiple sclerosis on immune modulating treatments Francesca Napoli (Università degli studi di Roma Tor Vergata – Rome, Italy) #26 Astrocyte TrkB supports injury in ischemic stroke Emanuela Colombo (San Raffaele Scientific Institute – Milan, Italy) #28 Application of GreatNector as a data-driven workflow in Multiple Sclerosis Alessandro Maglione (Department of Clinical and Biological Sciences, University of Turin – Turin, Italy) #29 Nutrient-specific control of immunological self-tolerance in Experimental Autoimmune Encephalomyelitis Claudia Russo (Fondazione Santa Lucia IRCCS – Rome, Italy) #30 Identification of immuno-miRs as biomarkers associated with response to immunosuppressive treatment in myasthenia gravis Nicola Iacomino (Fondazione IRCCS Istituto Neurologico Carlo Besta - Milan, Italy) #31 Whole miRNome sequencing in myasthenia gravis thymus reveals dysregulated miRNA/target gene networks implicated in autoimmunity Maria Cristina Tarasco (Fondazione IRCCS Istituto Neurologico Carlo Besta - Milan, Italy) #38 Prognostic relevance of quantitative and longitudinal CASPR2 and LGI1 antibody testing in patients with autoimmune encephalitis. Ruggero Barnabei (Fondazione Mondino – Pavia, Italy) #39 Proinflammatory MAIT cells react to gut flora yeasts and infiltrate brain in multiple sclerosis patients Gisella Guerrera (Santa Lucia Foundation IRCCS – Rome, Italy) #43 Characterization of new bioactive molecules for the treatment of neuroinflammatory and neurodegenerative diseases Pallab Majumder (University of Verona – Verona, Italy) #45 Isolated Retrograde Amnesia in anti-CASPR2 Encephalitis: A Case Series and Systematic Literature Review Antonio Malvaso (IRCCS "C. Mondino" Foundation - National Neurological Institute – Pavia, Italy) #46 Subgroup outcomes from RAISE: A randomised, Phase 3 trial of zilucoplan in generalised myasthenia gravis Matteo Gastaldi (IRCCS Mondino Foundation - Pavia, Italy) #47 Long-term efficacy and safety of symptom-driven cyclic rozanolixizumab treatment in patients with generalised myasthenia gravis: A pooled analysis of a Phase 3 study and two open-label extension studies Matteo Gastaldi (IRCCS Mondino Foundation - Pavia, Italy) #48 Re-emergence of T lymphocytes-mediated synaptopathy in progressive multiple sclerosis Sara Balletta (IRCCS Ist. Neurologico Neuromed – Rome, Italy) #49 MiRNA-106a in cell- free cerebrospinal fluid as signature of early Relapsing Multiple Sclerosis Virginia Manuti (Università degli studi di Foggia – Foggia, Italy) #51 Head-to-head comparison of fixed versus live cell-based assays for AQP4-IgG detection in real-life diagnostic setting Mario Risi (University of Campania "Luigi Vanvitelli" – Naples, Italy) #52 An atypical case of progressive disease in MOGAD Massimiliano Ugo Verza (University of Florence – Florence, Italy) #55 Synaptic sexual dimorphism in multiple sclerosis and experimental autoimmune encephalomyelitis mouse model Alice Tartacca (Tor Vergata University, Rome, Italy – Rome, Italy) #58 Immunological patterns characterizing anti-CD20 therapy in Multiple Sclerosis: a longitudinal study Manolo Sambucci (IRCCS Fondazione Santa Lucia – Rome, Italy)
“Morirò d’Amore” (G. Russo) 14:15 - 18:15
ADULT & PAEDIATRIC MS Chairs: Massimiliano Di Filippo (Perugia) & Claudio Procaccini 14:15-14:45 | Metabolic Regulation of B-cell function and Implication in Multiple Sclerosis Pathogenesis and Therapy Amit Bar-Or (University of Pennsylvania - Philadelphia (PA), USA) 14:45-15:15 | T cell specificity and disease heterogeneity in Multiple Sclerosis Mireia Sospedra (University Hospital Zurich - Zurich, Switzerland) Oral Presentations 15:15-15:30 | #57 Deciphering immune changes in PwMS under DMF, Ocrelizumab and Cladribine by high-dimensional flow cytometry Mario Picozza (Santa Lucia Foundation - Rome, Italy) 15:30-15:45 | #44 Multiple Sclerosis patients on immunomodulatory drugs develop an exhaustive antigen-specific T and B cell response after three doses of SARS-CoV-2 mRNA vaccination Sara De Biasi (University of Modena and Reggio Emilia – Modena, Italy) 15:45-16:00 | #60 Study of adaptive immunity in subjects with multiple sclerosis treated with cladribine Marta Pirronello (Fondazione Santa Lucia – Rome, Italy) 16:00-16:15 | #59 Impact on innate immunity of anti-CD20 therapy for MS Silvia Corbisiero (IRCCS Santa Lucia Foundation – Rome, Italy)
Coffee Break 16:15 - 16:45
Young Session | Encephalitis Lethergic Chairs: Emanuela Colombo (Milan) & Alessandro Bani (Verona) 16:45-17:30 | Encephalitis Lethargic: 100 years after the epidemic Francesco Brigo (Hospital of Merano (SABES-ASDAA) - Meran, Italy) 17:30-18:15 | Round Table Discussion
AINI GENERAL ASSEMBLY 18:15 - 19:15
AINI DINNER 21:00...

Day 4 | Saturday May 6

Day 4 | Saturday May 6
Cocciu D'Amuri" (by Tinturia in "Andiamo a quel paese") 09:30 - 12:00
PSYCHONEUROIMMUNOLOGY Chairs: Clara Ballerini (Florence) & Diego Centonze (Rome) 09:30-10:00 | Circulating immune cell composition and activation status associate with brain white matter microstructure in Mood Disorders Francesco Benedetti (Milan) Oral Presentations 10:00-10:15 | #30 Identification of immuno-miRs as biomarkers associated with response to immunosuppressive treatment in myasthenia gravis Nicola Iacomino (Fondazione IRCCS Istituto Neurologico Carlo Besta – Milan, Italy) 10:15-10:30 | #54 Single-cell phenotyping of B cells to investigate Rituximab response in patients with Myasthenia Gravis Jacopo Morroni (Policlinico Universitario "A. Gemelli" IRCCS – Rome, Italy) 10:30-10:45 | #53 High-fat diet exacerbates inflammatory synaptic damage and disease course in clinical and experimental multiple sclerosis Francesca De Vito (Istituto Neurologico Mediterraneo (INM) Neuromed IRCCS – Pozzilli, Italy) 10:45-11:00 | #20 The short-chain fatty acid butyrate decreases the regulatory function of human natural killer cells and promotes their maturation Federico Carlini (IRCCS Ospedale Policlinico San Martino - Genova, Italy)
Coffee Break 11:00 - 11:30
AINI CONTROLLO QUALITÀ Chair: Roberto Furlan (Milan) 11:30-12:00 | AINI Controllo qualità Matteo Gastaldi (Pavia) 12:00-13:00 | AINI Awards & Final Remarks