The Domingos laboratory researches neuroimmune mechanisms underlying obesity. They discovered the functional neuro-adipose junctions between white adipocytes and the sympathetic nervous system that are necessary and sufficient for fat mass reduction via norepinephrine (NE) signaling (Cell 2015, Nature Comm 2017). They discovered Sympathetic neuron-Associated Macrophages (SAMs) that import and metabolize NE. Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake (Nature Medicine, 2017).
Ana Domingos is funded by HHMI, the Welcome Trust, ERC, HFSP, EMBO. She trained with Leslie Vosshall and Jeffrey Friedman at The Rockefeller University and is Associate Professor of Neuroscience at University of Oxford. She graduated in mathematics.
1. Zeng W*, Pirzgalska RM*; Pereira MMA; Kubasova N; Barateiro A; Seixas E; Lu YH; Kozlova A; Voss H; Martins GG; Friedman JM, Domingos AI (2015). Sympathetic Neuro-Adipose Connections Mediate Leptin-Driven Lipolysis. Cell. 163(1):84–94, doi: http://dx.doi.org/10.1016/j.cell.2015.08.055. Features: —Ruud&Bruening (2015). Metabolism: Light on leptin link to lipolysis. Nature —Bray( 2015). Zapping fat in WAT, NatureRev.Neuroscience —News & Views (2015). A closer look at the nerves that slim down your fat cells, Science —Varela & Horvath (2015). A Sympathetic View on Fat by Leptin, Cell
2. Pereira MMA, Mahú I, Seixas E, Martinéz-Sánchez N, Kubasova N, Pirzgalska RM, Cohen P, Dietrich MO, López M, Bernardes GJL, Domingos, AI A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. (2017) , Nature Communications.
3. Roksana M Pirzgalska*, Elsa Seixas*, Jason S Seidman, Verena M Link, Noelia Martínez Sánchez, Inês Mahú, Raquel Mendes, Vitka Gres, Nadiya Kubasova, Imogen Morris, Bernardo A Arús, Chelsea M Larabee, Miguel Vasques, Francisco Tortosa, Ana L Sousa, Sathyavathy Anandan, Erin Tranfield, Maureen K Hahn, Matteo Iannacone, Nathanael J Spann, Christopher K Glass & Ana I Domingos (2017). Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine. Nature Medicine. doi:10.1038/nm.4422 Features: —Jung, S (2017). Year in Review. Nature Reviews Immunology —Bradley, C (2017). Specialized macrophages contribute to obesity. NatureRev.Endocrinol. —Scanlon, S (2017). Unusual macrophages contribute to obesity. Editor’s Choice, Science —Czech, MP (2017). Macrophages dispose of catecholamines in adipose tissue. NatureMedicine —Guttenplan et al. (2018). Play It Again, SAM: Macrophages Control Peripheral Fat Metabolism, TrendsImmunology *co-authors