Day 3 | September 18

SEPTEMBER 18
NEUROIMMUNOLOGY OF COGNITION AND BEHAVIORAL DISORDERS
CHAIRS: Martina Severa & Roberto Furlan
LECTURE VII
09:00-09:45: Peripheral and central processes in MS Cinthia Farina (San Raffaele Milan, Italy)

ORAL PRESENTATIONS
09:45-10:05: TrkB signalling in astrocytes may promote demyelination by altering copper transport Emanuela Colombo (IRCCS San Raffaele Hospital, Milan, Italy)
10:05-10:25: Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: a multimodal magnetic resonance imaging study Francesco Benedetti (San Raffaele Hospital, Italy)
10:25-10:45: Reconstruction and analysis of amyloid beta and microglia interaction networks in experimental models of Alzheimer’s disease Aferdita Suli (University of Verona, Italy)

10:45-11:15 COFFEE BREAK
DEMYELINATING DIESASES II
CHAIRS: Roberta Magliozzi
LECTURE VIII
11:15-12:00: Regulation of phagocyte phenotypes in neuroinflammatory lesions Martin Kerschensteiner (University of Munich, Germany)

ORAL PRESENTATIONS
12:00-12:15: Covaxims: a prospective study for the evaluation of immunogenicity of anti-SARS-COV2 vaccines in patients with MS Matilde Inglese (University of Genoa, Italy)
12:15-12:30: Analysis of TR1-like cells in Multiple Sclerosis Jens Geginat (INGM Milano, Italy)
12:30-12:45: Clinial relevance of longitudinal antibody titres in patients with MOGAD Giacomo Greco (IRCCS National Neurological Institute C. Mondino Foundation, Italy)
12:45-13:00: Multifaceted activities of dimethylfumarate on systemic immune asset of multiple sclerosis patients Fortunata Carbone (Coniglio Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy/IRCCS Fondazione Santa Lucia, Roma, Italy)

13:00-14:30 LUNCH BREAK
BRAIN REGENERATION DURING NEUROINFLAMMATORY DISEASES
CHAIRS:Georgia Mandolesi & Antonio Uccelli
LECTURE IX
14:30-15:15: Remyelination mechanisms and therapies: new directions and challenges multiple sclerosis V. Wee Yong (University of Calgary, Canada)

ORAL PRESENTATIONS
15:15-15:35: Involvement of a non-canonical smoothened receptor signalling in mouse CNS demyelination Antonella Ragnini-Wilson (University of Rome Tor Vergata, Italy)
15:35-15:55: Mesenchymal stem cells for Multiple Sclerosis: effect of treatment on peripheral immune cells Alice Laroni (IRCCS Ospedale Policlinico San Martino, Italy)
15:55-16:15: Labelled nano vesicles from adipose mesenchymal stem cells target inflamed lymph nodes in chronic experimental autoimmune encephalomyelitis Ermanna Turano (University of Verona, Italy)
16:15-16:35: Choroid plexus as source of chronic stimulation of intrathecal inflammation in progressive multiple sclerosis Roberta Magliozzi (University of Verona, Italy/Imperial College London, UK)

16:35-17:00 COFFEE BREAK
POSTER SESSION
CHAIRS: Ermanna Turano & Jens Geginat
16:30-18:30
Exploring by protein microarray the autoantibodies repertoire in Multiple Sclerosis Patients Alberto Carnasciali (Università degli Studi di Firenze, Italy)

T-cell receptor repertoire architecture in cerebrospinal fluid: insights on a Primary-Progressive Multiple Sclerosis patient Roberta Amoriello (University of Florence, Florence, Italy)

Effects of MAGL inhibitor on striatal synaptic dysfunction in a mouse model of multiple sclerosis Krizia Sanna (Università Tor Vergata, Rome, Italy)

Efgartigimod: A Novel FcRn Antagonist in the Treatment of Autoimmune Diseases Alessandro Pinna (argenx, Ghent, Belgium)

MOGAD vs NMOSD DIAGNOSIS: THE ROLE OF LIVE CELL BASED ASSAY IN MOG ANTIBODY DETECTION Maria Teresa Ferrò (ASST Crema, Italy, Crema, Italy)

Usefulness of cholinergic receptor subtypes mRNA levels in PBMCs as a marker for neuroinflammatory diseases Marcella Reale (University G.D. Annunzio, Italy)

Intratechal and peripheral protein inflammatory profiles only partially correlate in MS patients at time of diagnosis Francesco Pezzini (University of Verona, Italy)

Toward a new tolerogenic strategy: dendritic cells educated upon resolvins as possible therapeutic agents in neuroinflammation Francesco Pezzini (University of Verona, Italy)

Toward a new tolerogenic strategy: dendritic cells educated upon resolvins as possible therapeutic agents in neuroinflammation Giovanni Ferrara (IRCCS Ospedale Policlinico San Martino, Genoa, Italy)

Immunometabolic reprogramming by tetramerization of pyruvate kinase M2 reduces dendritic cell activation. Marta Bottero (IRCCS Ospedale Policlinico San Martino, Genoa, Italy)

β3-adrenergic receptor expressing stromal cells in thymus control Treg generation and release of newly generated lymphocytes Maria Cristina Mariani (IRCCS Polyclinic Hospital San Martino, Genoa, Italy)

Differential regulation of hematopoiesis and regulatory T-cell generation in mouse models of glioma Erika Ricci (IRCCS Polyclinic Hospital San Martino, GENOA, Italy)

Transcriptional analysis by NGS technology of lncRNAs in EVs derived from THP-1 cell line Annamaria Finardi (IRCCS Ospedale San Raffaele, Milan, Italy)

The impact of storage on extracellular vesicles: a systematic study Stefano Gelibter (IRCCS Ospedale San Raffaele, Milan, Italy)

Gisella Guerrera (Fondazione Santa Lucia, Neuroimmunology Unit, Roma, Italy)

The purinergic receptor P2RY12 in glial inflammation and demyelination Chiara Cordiglieri (Istituto Nazionale Genetica Molecolare (INGM), Milan, Italy)

Clinical and immunological characteristics of neuronal intermediate filament autoimmunity Claudia Papi (Università Cattolica del Sacro Cuore - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy)

γδ T cell-mediated neurotoxicity in in vitro models of Alzheimer’s disease Nicola Lopez (University of Verona, Italy)

innovative strategies for biomarkers validation in amyotrophic lateral sclerosis Alice Verdiani (IRCSS Fondazione Santa Lucia, Neuroimmunology Unit, Rome, Italy)