Day 2 | September 17

SEPTEMBER 17
ADAPTIVE IMMUNITY MECHANISMS IN BRAIN NEUROINFLAMMATION
CHAIRS: Clara Ballerini & Matteo Gastaldi
LECTURE III
09:00-09:45: Autoimmune humoral immunological memory: the bad and the good Elisabetta Traggiai (Novartis Institute for Biomedical Research, Switzerland)

ORAL PRESENTATIONS
09:45-10:05: Treatment with ocrevus does not inhibit antiviral T-cell responses in persons with MS after SARS-COV-2 infection Roberto Furlan (San Raffaele Hospital Milan, Italy)
10:05-10:25: AgRP neurons control lymphoid hematopoiesis and Treg generation through beta-3 adrenergic receptor-expressing stromal cells Tiziana Vigo (IRCCS Ospedale Policlinico San Martino, Genoa, Italy)
10:25-10:45: Significance of MOG antibodies in CSF: a retrospective multicenter study Sara Carta (University of Verona, Italy)

10:45-11:15 COFFEE BREAK
THE INTERPLAY BETWEEN NEURODEGENERATION AND NEUROINFLAMMATION
CHAIRS: Nicole Kerlero de Rosbo & Diego Centonze
LECTURE IV
11:15-12:00: Neuronal vulnerability and multi lineage diversity in multiple sclerosis Lucas Schirmer (University of Heidelberg, Germany)

ORAL PRESENTATIONS
12:00-12:20: The role of meningeal stroll cells in brain auto-reactive immune cell regulation Ilaria Decimo (University of Verona, Italy)
12:20-12:40: The role of the meningeal layers in CNS autoimmunity Francesca Odoardi (University Medical Center Göttingen)
12:40-13:00: The effect of exosomes derived from adipose mesenchymal stem cells in microglial model of ALS Sylwia Dabrowska (University of Verona, Italy)

13:00-14:30 LUNCH BREAK
FOCUS ON INNATE IMMUNITY
CHAIRS: Elena Zenaro & Giuseppe Locatelli
LECTURE V
14:30-15:15: Spatial and temporal heterogeneity of microglial cells during homeostasis and demyelination Roman Sankowski (University of Freiburg, Germany)

ORAL PRESENTATIONS
15:15-15:35: LFA-1 intern controls microglia-neutrophil interaction in the central nervous system during experimental autoimmune encephalomyelitis Gabriele Angelini (University of Verona, Italy)
15:35-15:55: CSF levels of CXCL12 and Osteopontin as early markers of primary progressive multiple sclerosis Damiano Marastoni (University of Verona, Italy)
15:55-16:15: Detection of neuroinflammation using iron-sensitive magnetic resonance imaging Simon Hametner (Medical University of Vienna, Austria)

16:15-16:45 COFFEE BREAK
DEMYELINATING DISEASES I
CHAIRS: Giovanna Borsellino & Gianvito Martino
LECTURE VI
16:45-17:30: Lymphocyte trafficking to the CNS - does provenance matter? Thomas Korn (Technical University of Munich, Germany)

ORAL PRESENTATIONS
17:30-17:45: CD28 and associated-class-1A-P13K regulates the cellular metabolic programs correlated/associated to pro-inflammatory T cell responses in Multiple Sclerosis Manolo Sambucci (Santa Lucia Fondation, Italy)
17:45-18:00: Cladribine modifies the expression of deoxycytidine kinase and its phosphorylated isoforms in in-vitro activated T cells Federico Carlini (San Martino Hospital, Italy)
18:00-18:15: The MS-associated EBNA2 alleles show functional relevance in virus-host interaction in a cellular model in infection Rosella Mechelli (San Raffaele Roma Open University, Italy)
18:15-18:30: GWAS associated variants, non-genetic factor, and transient transcrpritome in Multiple Sclerosis etiopathogenesis: a colocalization analysis Gianmarco Bellucci (Sapienza University of Rome, Italy)

18:30 AINI Annual General Assembly

19:30 Dinner & AINI annual football match