Prof. Vincenzo Barnaba MD
Dipartimento di Medicina Interna e Specialità Mediche
Sapienza Università di Roma
Rome | Italy
Vincenzo Barnaba (VB) carries out his scientific research mainly at the Institue Pasteur, Fondazione Cenci Bolognetti – Dipartimento di Medicina Interna e Specialit Mediche, Sapienza Universit di Roma. VB has been active as an immunologist for 40 years. The group lead by VB has a long-standing interest in the pathogenesis of immune-mediated diseases, including autoimmune and viral (hepatitis viruses, HIV) diseases, and tumor immunity. In particular, the VB group’s research aims at establishing the role of HBV and HCV in inducing chronic infection, the role of viruses in inducing autoimmunity, such as the ability of HIV to unveil cryptic selfepitopes, and the mechanisms by which T cell response against tumor antigens can be unleashed.
Other VB research fields are the following:
1. Dynamics of CD8 T cell responses against viral and tumor antigens;
2. Mechanisms of cross-presentation of exogenous (pathogen- or tumor-associated) antigens;
3. Mechanisms influencing the differentiation of memory or effector T cells during immunopathology (chronic viral infections, tumors);
4. Mechanisms controlling T cell responses (i.e., by regulatory T cells [Tregs]) in chronic infections, autoimmunity and tumors;
5. Proteomic analysis of tumor cells addressed for identifying novel immunogenic self- or tumor antigens;
6. Proteomic analysis of tumor secretomes addressed for identifying novel immune checkpoints;
7. Studies on the role of viruses in unveiling cryptic self-epitopes.