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Day 1
06 Mag 2019
15:00 - 17:00

Opening session

Borsellino, Giovanna
Constantin, Gabriela
Oral

034 – Coagulation Up-regulation As Expression Of Innate Immune Activation In Relapsing-remitting Multiple Sclerosis

Tatiana Koudriavtseva
Department Of Clinical Experimental Oncology, Irccs Regina Elena National Cancer Institute, Rome, Italy
Oral

038 – Age-related Alterations Of Neutrophils In Ischemic Stroke

Giorgia Serena Gullotta
San Raffaele Scientific Institute, Inspe- Neuroimmunology Unit, Milan, Italy
Oral

072 – Investigating The Role Of Selective Autophagy In Multiple Sclerosis (ms)

Flavie Strappazzon (1, 2)
European Center for Brain Research, IRCCS Fondazione Santa Lucia, Rome, Italy (1) - Department of Biology, University of Tor Vergata, Rome, Italy (2)
17:00-19:00

Poster session

Bonechi, Elena
Volpe, Elisabetta
Poster

016 – Are There Antibodies To Neuronal Surface Antigens In Patients Given A Diagnosis Of Neurodegenerative Disorder?

Maria Pia Giannoccaro
University Of Bologna, Department Of Biomedical And Neuromotor Sciences, Bologna, Italy
Poster

017 – Intrinsic Factor Recognition Promotes T Helper 17 / T Helper 1 Autoimmune Gastric Inflammation In Patients With Pernicious Anemia

Jacopo Bitetti
Department of Experimental and Clinical Medicine, University of Florence, Italy
Poster

022 – Endogenous Neural Stem Cells Of The Subventricular Zone Regulate The Functionality Of The Striatum.

Erica Butti
Neuroimmunology Unit, Division of Neuroscience, INSPE, San Raffaele Hospital, Milan, Italy
Poster

023 – Mog35-55 Specific T Cells Loaded With Anti-cd20 Monoclonal Antibody Bound To Iron Oxide Nanoparticles Mitigate Eae In Mice

Alberto Carnasciali
Università Degli Studi Di Firenze, Dipartimento Di Neurofarba, Università Di Firenze, Firenze, Italy
Poster

030 – Ex Vivo Assessment Of The Effect Of Fingolimod On New Pathways Involved In Neuroprotection

Federico Carlini
University Of Genoa, Department Of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health Unit (dinogmi), Genoa, Italy
Poster

031 – Microglial Extracellular Vesicles As Therapeutic Vector For Neuroinflammation

Giulia Marostica
San Raffaele Scientific Institute, Clinical Neuroimmunology, Milan, Italy
Poster

035 – Synaptic Proteins And Neuronal Circuits Involved In Brain Plasticity Are Modulated During Relapsing-remitting Experimental Autoimmune Encephalomyelitis.

Mariagrazia Valentini
Università Cattolica Del Sacro Cuore, Institute Of General Pathology, Rome, Italy
Poster

036 – Multi Fold Transplant Strategy Of Engineered Neural Stem Cells To Promote Remyelination And Neuroprotection In Multiple Sclerosis

Luca De Feo
Università Vita E Salute San Raffaele, Viale Sabotino 12, Milano, Italy
Poster

039 – Astrocytic Shcc/rai Dampens Cd39 Enzyme Activity In Astrocytes

Domiziana De Tommaso
University Of Siena, Department Of Life Science, University Of Siena, Siena, Italy
Poster

051 – Lymphocytes Flow Cytometric Analysis Changes During Cladribine Therapy In Highly Active Multiple Sclerosis Patients

Concetta Domenica Gargano
University Of Bari - Aldo Moro, Department Of Basic Medical Science, Neuroscience And Sense Organs, Bari, Italy
Poster

057 – Does Nerve-glial Antigen 2 (ng2) Play A Role In Dendritic Cell Activation?

Giovanni Ferrara
Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, L.go P. Daneo, 3, 16132, Genoa, Italy
Poster

062 – Nanoparticles Are Able To Promote The Polarization To Itreg And Inhibit Polarization To Th1 Of Mbp-specific T Cells From Ms Patients

Mariagrazia Valentini
Institute Of General Pathology, Fondazione Policlinico Universitario A. Gemelli - Irccs, Rome, Italy
Poster

064 – Interleukin-9 Expressed In Central Nervous System Of Multiple Sclerosis Patients Targets Astrocytes

Gloria Donninelli
Irccs Santa Lucia Foundation, Neuroimmunology Unit, Rome, Italy
Poster

066 – Clinical And Demographic Traits Of Multiple Sclerosis Patients Infected By Risky Ebna2 Alleles

Emanuele Morena
Centre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University, Rome
Poster

067 – Isolation Of Exosomes From Human Plasma: Comparison Of Size Exclusion Chromatography Columns With Ultracentrifugation.

Stefano Gelibter
San Raffaele Hospital, Institute Of Experimental Neurology - Clinical Neuroimmunology Unit, Milan, Italy
Poster

070 – Gene Expression Profiles Of Proteins Involved In Cladribine Metabolism And Their Possible Correlation With Epstein-barr Virus Variants

Grazia Manfre (1)
San Raffaele Roma Open University and IRCCS San Raffaele Pisana, Rome, Italy
Poster

079 – Distinct Protein Expression Networks Are Activated In Microglia Cells After Stimulation With Inf-gamma And Il-4

Annamaria Nigro
San Raffaele Scientific Institute, Division Of Neuroscience, Institute Of Experimental Neurology, Milan, Italy
Poster

085 – Antibodies to neuronal surface proteins in Tourette Syndrome: preliminary results in a European paediatric cohort

Baglioni V
Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy
19:00

Welcome cocktail

Day 2
07 Mag 2019
09:00 - 10:30

Round Table: A conversation on immunometabolism

Furlan, Roberto
Lecture

Control of immunity by amino acid metabolism

Matarese, Giuseppe
Murray, Peter
10:30 - 11:00

Coffee Break

11:00 - 13:00

Neurodegeneration I: Molecular biology of the neuron

Di Filippo, Massimiliano
Farina, Cinthia
Oral

047 – Siponimod Supports Physiological And Anti-oxidant Actions Of Human Astrocytes And Protects From Astrocyte-induced Neurodegeneration

Emanuela Colombo
San Raffaele Scientific Institute, Institute Of Experimental Neurology (inspe), Division Of Neuroscience, Milan, Italy
Oral

073 – Dopamine Inhibits Human Cd8+ Treg Function Through D1-like Dopaminergic Receptors

Gilberto Filaci (1, 3))
Center of Excellence for Biomedical Research/Department of Internal Medicine, University of Genoa, Italy - IRCCS Ospedale Policlinico San Martino, Genoa Italy (1) - Biotherapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa Italy (3)
Oral

009 – Glial And Synaptic Responses To Localized Neuroinflammation: The Case Of Spinal Networks In Organotypic Slices

Giulia Panattoni
International School for Advanced Studies (SISSA/ISAS), Trieste, Italy
13:00 - 14:30

Lunch

14:30 - 16:15

Neurodegeneration II – Clinical aspects/therapy of neurodegeneration

Magliozzi, Roberta
Mandolesi, Georgia
Oral

044 – Exposure To Cladribine Results In Dck Overexpression In Activated Cd4+ T Cells

Federico Carlini
University Of Genoa, Department Of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health Unit (dinogmi), Genoa, Italy
Oral

042 – Intrathecal Inflammation Predicts The Disease Course In Multiple Sclerosis: A Combined Neuropathological And 4 Yr Longitudinal Clinical Study.

Roberta Magliozzi (1, 2)
Dept. of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Policlinico Verona, Italy (1) - Division of Brain Sciences, Wolfson Neuroscience Laboratories, Imperial College Faculty of Medicine, London, UK (2)
Oral

084 – Implementing a drug-screening platform with mouse and human neurons for multiple sclerosis (MS) to identify compounds with a neuroprotective potential and assess disease specific dysfunctions.

Ottoboni Linda
San Raffaele Scientific Institute, Division of Neuroscience - INSPE - Institute of Experimental Neurology, Neuroimmunology Unit
Oral

083 – Dna Threads Released By Activated Cd4+ T Lymphocytes Provide Autocrine Co-stimulation.

Rosetta Pedotti
Department Of Clinical Neuroscience, Fondazione Irccs Istituto Neurologico Carlo Besta
16:15 - 16:45

Coffee Break

16.45 - 17:45

Demyelinating Diseases I – Injury and repair of myelin sheaths

Kerlero de Rosbo, Nicole
Ottoboni, Linda
Oral

029 – Sphingolipid Alerts To Distinguish Inflammation From Demyelination In Multiple Sclerosis

Davide Visigalli
Dinogmi, University Of Genoa And Irccs San Martino Hospital, Genoa, Italy
Oral

061 – Extracellular Vesicles Mediate Detrimental And Protective Action Of Microglia On Myelin Lesion

Marta Lombardi (1, 2)
IRCCS Humanitas, via Manzoni 56, 20089 Rozzano, Italy (1) - CNR Institute of Neuroscience, via Vanvitelli 32, 20129 Milano, Italy (2)
17:45

AINI General Annual Assembly

Day 3
08 Mag 2019
09:00 - 10:45

Demyelinating Diseases II – The therapeutic approach to demyelinating diseases

Ballerini, Clara
Ristori, Giovanni
Oral

005 – T Cell Receptor Repertoire Dynamics Is Tuned By Treatments In Rrms

Roberta Amoriello
Università Degli Studi Di Firenze, Dipartimento Neurofarba, Firenze, Italy
Oral

082 – Development of a high sensitive molecular assay to improve individualized monitoring of Rituximab treatment in patients with NMOSD

Fabiana Marnetto (1, 2)
SCDO Neurologia-CRESM, Neuroscience Institute Cavalieri Ottolenghi (NICO); AOU San Luigi Gonzaga, Orbassano, Turin (1) - Department of Neuroscience, University of Turin (2) - Department of Oncology, University of Turin, Candiolo (Turin) (3)
Oral

055 – Mir-142-3p As A New Molecular Target Of Dmf To Prevent Inflammation-driven Synaptopathy And Motor Disability In Experimental Ms

Francesca De Vito
Unità di Neurologia, IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli (IS), Italy
10:45 - 11:15

Coffee break

11:15 - 13:00

Autoimmune encephalitis I – B lymphocyte biology in autoimmune diseases

Angelini, Daniela
Marnetto, Fabiana
Oral

049 – The Novel Role Of Hnf4a In Multiple Sclerosis And Experimental Autoimmune Encephalomyelitis

Maria Maddalena Valente
Institute Of Experimental Neurology (inspe), San Raffaele Scientific Institute, Milan, Italy
Oral

053 – Saccharomyces Cerevisiae Sk1 Activates Human Plasmacytoid Dendritic Cells: Possible Implication In Multiple Sclerosis

Marta Corsetti (1, §)
Neuroimmunology Unit, IRCSS Fondazione Santa Lucia, Rome, Italy (1)
§ equally contributor authors
Oral

060 – Tim-1 Glycoprotein Mediates Neutrophil-dependent Damage During Brain Neuroinflammation

Jessica Arioli (1) - Anna Slanzi (1) - Elena Zenaro (1) - Silvia Dusi (1) - Enrica Caterina Pietronigro (1) - Barbara Rossi (1) - Nicola Lopez (1) - Davide Gioco (1) - Gabriele Angelini (1) - Gabriela Constantin (1)
University Of Verona, Department Of Medicine, Section Of General Pathology, Verona, Italy (1)
13:00 - 14:30

Lunch

14:30 -16:00

Autoimmune Encephalitis II – Therapeutic approaches

Benedetti, Luana
Iorio, Raffaele
Oral

028 – Homing Of Nanovesicles Derived From Adipose Mesenchymal Stem Cells In Experimental Autoimmune Encephalomyelitis.

Bruno Bonetti (1, 4)
University Of Verona, Department Of Neurosciences, Biomedicine And Movement Sciences, Verona, Italy (1) - Neurological Clinic, Hospital Of Verona, Verona, Italy (4)
Oral

026 – High Levels Of Perivascular Inflammation And Active White Matter Lesions At Time Of Death Are Associated With Rapidly Progressive Multiple Sclerosis

Damiano Marastoni (1, 2)
Wolfson Neuroscience Laboratories, Division of Brain Sciences, UK Multiple Sclerosis Tissue Bank, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK (1) - Dept. of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy (2)
Oral

032 – Assay Comparison In Myelin Oligodendrocyte Glycoprotein Antibodies Detection

Matteo Gastaldi
Irccs Mondino Foundation, Neuroncology-neuronflammation Unit, Neuroimmunology Laboratory, Pavia, Italy
16:00 - 16:30

Coffee break

16:30 - 18:30

Poster session

Gastaldi, Matteo
Gentile, Antonietta
Poster

007 – N-methyl-d-aspartate Receptor Antibody-related Pathologies And Pre-existent Mental State Disorders

Federico Massa
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Unit and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
Poster

008 – Cerebrospinal Fluid Free Light Kappa And Lambda Chains In Oligoclonal Band-negative Patients With Suspected Multiple Sclerosis

Diana Ferraro
Neurology Unit, Department Of Biomedical Metabolic And Neurosciences, University Of Modena And Reggio Emilia, Aou Modena, Modena, Italy
Poster

024 – Cd4+ T Cells Subsets Reconstitution After Alemtuzumab Treatment: A Six Year Prospective Immunological Study.

Valentina Bardina
Department of Clinical and Biological Sciences, University of Torino
Poster

033 – Immunomodulatory Effect Of Pregnancy On Leukocyte Populations In Patients With Multiple Sclerosis: A Comparison Of Peripheral Blood And Placental Tissue.

Serena Martire (1, 2 )
Clinical Neurobiology Unit, Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Turin, Italy (1) - Neurologia - CRESM (Centro Riferimento Regionale Sclerosi Multipla), AOU S. Luigi Gonzaga, Orbassano, Turin, Italy (2)
Poster

037 – Immunological Insights Into The Mechanisms By Which Rtx Is Effective In Neuromyelitis Optica Spectrum Disorders

Valentina Damato (1, 3)
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom (1) - Institute of Neurology, Department of Neuroscience, Catholic University, Rome, Italy (3)
Poster

040 – Candidate Genetic Drivers Of Seasonal Periodicity Of Relapses In Multiple Sclerosis

Virginia Rinaldi
Centre for Experimental Neurological Therapies, S. Andrea Hospital, Sapienza University, Rome, Italy
Poster

041 – Clinical Characteristics Immunological Accompaniments And Treatment Outcomes Of Autoimmune Cerebellar Ataxia

Claudia Papi)
Fondazione Policlinico Universitario "a. Gemelli" Irccs, Institute Of Neurology, Università Cattolica Del Sacro Cuore, Rome, Italy
Poster

043 – Clinical, Radiologic And Immunological Characteristics Of Adult Patients With Autoimmune Encephalitis: A Prospective Observational Study.

Gianvito Masi
Fondazione Policlinico Universitario "a. Gemelli" Irccs, Rome, Italy, Institute Of Neurology, Università Cattolica Del Sacro Cuore, Rome, Italy, Rome, Italy
Poster

046 – Pediatric Optic Neuritis And Anti Mog Antibodies: A Cohort Of Italian Patients, Looking For Prognostic Factors

Thea Giacomini (1, 6)
Unit of Children Neuropsychiatry, Istituto Giannina Gaslini, Genova, Italy (1) - Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy (6)
Poster

054 – Autoimmune Encephalitis And Csf Anti-glur3 Antibodies In An Ms Patient After Alemtuzumab Treatment

Anna Chiara Landi
Department of Neurosciences, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Centre for Experimental Neurological Therapies (CENTERS), Sapienza University, Rome, Italy
Poster

056 – Voluntary Running Wheel Protects Against Brain Damage And Motor Defects Induced By Cuprizone (cpz)

Livia Guadalupi
Synaptic Immunopathology Lab, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
Poster

058 – Reduction Of The Clinical Outcome In In Vivo Models Of Multiple Sclerosis Targeting S100b

Mariagrazia Valentini
Università Cattolica Del Sacro Cuore, Fondazione Policlinico Universitario A" Gemelli" Irccs, Rome, Italy
Poster

069 – Autoimmune Encephalitis Associated With Caspr2 Antibodies: A Diagnostic Challenge.

Martina Biggi
Neurology Unit, Careggi Hospital, University Of Florence, Neurofarba Department, Florence, Italy
Poster

074 – Increased Frequency Of Antibodies Against Neuronal Surface Antigens In Type 1 Narcolepsy With Complex Movement Disorders

Maria Pia Giannoccaro
University Of Bologna, Department Of Biomedical And Neuromotor Sciences, Bologna, Italy
Poster

075 – Sleep Disorders In Children With Pediatric Acute-onset Neuropsychiatric Syndrome (pans): A Polysomnographic Study

Antonella Gagliano
University Of Cagliari, A Cao Microcitemico, Cagliari, Italy
Poster

076 – Effects Of An Immunomodulating Therapy In Ms Measured By Deep Immunophenotyping

Mario Picozza
Santa Lucia Foundation, Neuroimmunology Unit, Rome, Italy
Poster

077 – Gut Flora, Mait Cells And Multiple Sclerosis: Effects Of Dimethyl Fumarate

Francesca Gargano
Neuroimmunology Unit, Santa Lucia Foundation, Rome, Italy
Poster

078 – Effects Of Pegylated Beta Interferon-1a On B Cells In Multiple Sclerosis

Gisella Guerrera (1)
Neuroimmunology Unit, Santa Lucia Foundation, Rome
18:30

AINI Football Match

20:00

Dinner

Day 4
09 Mag 2019
09:00 - 10:30

Neuroimmunology in mood and sleep disorders I – Immunology of Narcolepsy

Giannoccaro, Maria Pia
Zuliani, Luigi
Lecture

Autoreactive T cells in narcolepsy

Sallusto, Federica
Oral

021 – Th17/treg Cells, Related Cytokines And Non-neuronal Cholinergic System In Obstructive Sleep Apnea

Lucia Velluto
Villa Serena Hospital, Neurology Department, Città Sant'angelo, Pescara, Italy
Oral

020 – Longitudinal Data On White Matter And Immunological Alterations In The Various Phases Of Bipolar Disorder

Matilde Inglese
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health, Section Of Neurology, University Of Genoa And Irccs Ospedale Policlinico San Martino, Genoa, Italy
Oral

068 – Pd-l2 – Enriched Evs Contribute To Immunosuppression And Are A Promising Novel Marker In Neuro-inflammatory Diseases

Tommaso Croese
Inspe, Clinical Neuroimmunology Unit, San Raffaele Hospital, Milano, Italy
10:30 - 11:00

Coffee Break

11:00 - 12:30

Neuroimmunology in mood and sleep disorders II

Gagliano, Antonella
Severa, Martina
Oral

071 – Neuro-inflammatory Markers Correlate With White Matter Microstructure In Bipolar Disorder

Veronica Aggio
Irccs San Raffaele Hospital, Division Of Neuroscience, Psychiatry And Clinical Psychobiology Unit, Milan, Italy
Oral

010 – Sympathetic Nervous System Signals To Beta-3 Adrenergic Receptor-expressing Bone Marrow Cells Promote Lymphoid Hematopoiesis In Experimental Autoimmune Encephalomyelitis

Tiziana Vigo (1, 2)
Irccs Ospedale Policlinico San Martino, Unità Di Neuroscienze, Genoa, Italy (1) - University Of Genoa, Dinogmi, Genoa, Italy (2)
Oral

080 – Atf6 Increase Following Oxidized-low-density-lipoprotein Vaccination

Maira Gironi (1, 2)
San Raffaele Scientific Institute, Division of neuroscience - INSPE - Institute of Experimental Neurology, Neuroimmunology Unit (1) - San Raffaele Scientific Institute, Department of neurology (2)
12:30 - 12:45

Closing remarks